# 主题阅读| 身体和情绪的关系

【主题】：身体和情绪的关系

• 阅读推荐清单
• 翻译：基因图谱上的情绪障碍（Mood disorders on genetic spectrum），这是一篇科研报导。

# 阅读推荐清单

## 我的推荐

1、剑桥主题讲座——《身体》

2、《身体》：波兰Nowhere制作的90分钟喜剧影片, 腾讯视频就有，b站也可以搜到，波兰的（PS：全程…我感到非常压抑，所有人都是抑郁症和情绪障碍患者）

3、知乎的一篇文章，阅读时长十分钟：https://zhuanlan.zhihu.com/p/33412881

4、黄执中关于情绪沟通的视频内容，一个小时左右：b站链接https://www.bilibili.com/video/av42164412?p=2 黄执中: “辩论之神” 历史上唯一连续两届拿下国际华语辩论最高赛事的最佳辩手

5、 《情商课》—蔡康永的，喜马拉雅就可以搜到。 其中关于如何辨别、认识自己的情绪，如何与自己的情绪相处。（整套课程很长，如果想听，可以每天听一点，我个人理解它可以作为认识自己的一个入门级别的内容）https://www.ximalaya.com/search/%E6%83%85%E5%95%86%E8%AF%BE

6、《笛卡尔的错误：情绪、推理和大脑》：重磅推荐。作者是世界第一流的神经科学家，科学发现+理性逻辑+意识流。他的另一本书《感受发生的一切》，也很好。 豆瓣就可以搜到。 (书籍在各个网站上都有，可以自己买纸质版，也可以买电子版，也可以去盗版)

## 相关主题类阵地

• 了解最新关于心理健康的科研和新闻的一个阵地：《科学日报》的心理健康板块 https://www.sciencedaily.com/news/mind_brain/mental_health/

# 译|基因图谱上的情绪障碍

## 原文

Mood disorders on genetic spectrum

Date:February 4, 2020
Source:Elsevier

Summary: Researchers shed new light on the genetic relationship between three mood disorders associated with depression – major depression and bipolar disorder types 1 and 2 – in a new study.

Researchers shed new light on the genetic relationship between three mood disorders associated with depression – major depression and bipolar disorder types 1 and 2 – in a new study in the journal Biological Psychiatry, published by Elsevier.

“The clearest findings are a genetic distinction between type 1 bipolar and type 2 bipolar, and the greater similarity of type 2 bipolar to major depressive disorder,” said first author Jonathan Coleman, PhD, a statistical geneticist and postdoctoral fellow in the lab of senior author Gerome Breen, PhD at the Institute of Psychiatry, Neuroscience, and Psychology at Kings College London, UK.

Both types of bipolar disorder used to be referred to as ‘manic-depressive disorder’. Mania is a behavioral state associated with behavioral activation, euphoric or irritable mood, reduced need for sleep, impulsive behavior, impaired judgement, racing disorganized thoughts, impulsive behaviors, and frequently strongly held false beliefs (delusions) or hallucinations. Bipolar disorder type 1 is associated with mania and depression, while bipolar 2 is predominately associated with depression marked by mild symptoms reminiscent of mania, called hypomania.

The insights came from several extremely large datasets analyzed together. For their meta-analysis, Coleman, Breen and their co-authors combined genome-wide association studies from three large datasets of people with major depression and bipolar disorder to evaluate shared and distinct molecular genetic associations. Most of the data came from the large international Psychiatric Genomics Consortium. Additional data came from the UK Biobank, a major health resource established by the Wellcome Trust, and the online genetic service platform, 23andMe.

There are significant racial and ethnic differences in the findings from genome-wide association studies (GWAS). The findings of this study pertain only to people of European ancestry and findings might be different in other groups.

The authors also report that the genetic risk for these disorders was predictive of other traits as well. For example, the genetic risk for bipolar disorder was correlated with more educational attainment, while the heritable risk for major depressive disorder was associated with less education.

In the mouse brain, the authors also mapped the genetic risk for these disorders on to particular brain cell types using a sophisticated analytic strategy building on the pattern of genes expressed. They implicated serotonin neurons in the risk for both depression and bipolar disorder, while bipolar disorder distinctively involved GABA and glutamate neurons (nerve cell types also implicated in schizophrenia).

“We have long known that mood disorders are highly heterogeneous and the boundaries between types of mood disorders are often difficult to define clinically,” said John Krystal, MD, editor of Biological Psychiatry. “This new study suggests that there are aspects of genetic risk, and presumably brain function, that link forms of mood disorders, but there are also distinctions that may shed light on subtypes of depression that may have important implications for treatment.”

Ultimately, the researchers want to develop clinical tools to help predict if a first episode of depression is likely to persist as a disorder or progress into bipolar disorder. “Genetic data won’t ever replace clinical insight, but it might be a useful addition to clinical models,” said Coleman.

## 翻译

• 重度抑郁症和
• 1型双相情感障碍
• 2型双相情感障碍


- 重度抑郁症是由于患者个体内遗传系统（基因）存在异常，或后天环境的巨变所引起的一种情绪性功能障碍，以持久自发性的情绪低落为主的一系列抑郁症状。

- 双相情感障碍又称双相障碍，是指患者既有躁狂或轻躁狂发作，又有抑郁发作的一类情感障碍（心境障碍）。双相障碍是一种常见的精神障碍，国外流行病学调查显示双相障碍患病率1%～3%，发病年龄高峰期15～19岁，首次多为抑郁发作，常一至数次抑郁发作后再出现躁狂或轻躁狂发作。中国既往的研究(1993年)显示发病率在0.083%，不到0.1%，发病率比国外低。

双相I型=躁狂发作史+重性抑郁发作史
双相II型=轻躁狂发作史+重性抑郁发作史



Jonathan Coleman（高级遗传统计学和遗传学博士）说：“最明显的发现是1型双相情感障碍与2型双相情感障碍之间的遗传区别，以及2型双相情感障碍与重度抑郁症之间的相似性更高”

1型双相情感障碍与躁狂和抑郁症相关，而2型双相情感障碍主要与以轻躁狂症状为特征的抑郁症有关，让人联想到躁狂症，称为轻躁狂。

“我们早就知道情绪障碍是高度异质的，并且情绪障碍类型之间的界限通常很难在临床上定义，” 生物学精神病学编辑约翰·克里斯塔尔（John Krystal）表示。“这项新的研究表明，遗传风险的某些方面，可能是脑功能，与情绪障碍的形式有关，但也有一些区别可能会揭示出对治疗可能具有重要意义的抑郁症亚型。”